Genotype Frequency to Phenotype Probability Calculator

Genotype Frequency to Phenotype Probability Calculator

How to Use This Tool:

This tool helps calculate the probability of different phenotypes based on the frequencies of the three possible genotypes (AA, Aa, aa) for a single gene with two alleles (A and a).

Input Frequencies:

  • Enter the percentage frequency for each genotype: AA, Aa, and aa.
  • The sum of these three frequencies **must** be 100%. The tool will validate this.

Dominance Pattern:

  • Complete Dominance: If allele 'A' is completely dominant over 'a', then individuals with genotypes 'AA' and 'Aa' will express the same dominant phenotype. Only 'aa' individuals will express the recessive phenotype.
  • Incomplete Dominance / Codominance: In these cases, each genotype (AA, Aa, aa) results in a distinct phenotype. For example, in incomplete dominance, 'Aa' might show an intermediate phenotype. In codominance, both 'A' and 'a' might be expressed simultaneously (e.g., blood types).

Calculation Logic:

  • Complete Dominance:
    • Probability of Dominant Phenotype: Frequency(AA) + Frequency(Aa)
    • Probability of Recessive Phenotype: Frequency(aa)
  • Incomplete Dominance / Codominance:
    • Probability of Phenotype for AA: Frequency(AA)
    • Probability of Phenotype for Aa: Frequency(Aa)
    • Probability of Phenotype for aa: Frequency(aa)

**Disclaimer:** This tool is for **educational and conceptual understanding only**. It uses simplified Mendelian inheritance principles for demonstration. It is **NOT** intended for actual genetic analysis, medical diagnosis, or any real-world scientific or health decision-making. Real genetic traits can be influenced by multiple genes, environmental factors, and complex interactions not accounted for here. For accurate genetic analysis, please consult qualified geneticists or healthcare professionals.

Probability of Phenotype for aa: ${freqaa.toFixed(2)} %

`; pdfResults = { 'Dominance Pattern': 'Incomplete Dominance / Codominance', 'Prob. Phenotype for AA': freqAA.toFixed(2) + ' %', 'Prob. Phenotype for Aa': freqAa.toFixed(2) + ' %', 'Prob. Phenotype for aa': freqaa.toFixed(2) + ' %' }; } phenotypeProbabilitiesResultEl.innerHTML = resultsHTML; outputSectionEl.style.display = 'block'; // Store data for PDF outputData = { inputs: { 'Frequency AA': freqAA.toFixed(2) + ' %', 'Frequency Aa': freqAa.toFixed(2) + ' %', 'Frequency aa': freqaa.toFixed(2) + ' %' }, results: pdfResults }; console.log('[DEBUG] Calculation successful.'); } catch (e) { console.error('[ERROR] Error in calculateProbabilities:', e); displayError('An error occurred during calculation. Check console for details.'); } } // Function to hide the output section function hideOutput() { console.log('[DEBUG] hideOutput called.'); const outputSection = document.getElementById('outputSection'); if (outputSection) { outputSection.style.display = 'none'; outputData = {}; // Clear output data when hidden } } // Function to reset the form fields function resetForm() { console.log('[DEBUG] resetForm called.'); try { hideError(); hideOutput(); document.getElementById('freqAA').value = '25'; document.getElementById('freqAa').value = '50'; document.getElementById('freqaa').value = '25'; document.getElementById('dominancePattern').value = 'complete'; console.log('[DEBUG] Form reset successful.'); } catch (e) { console.error('[ERROR] Error in resetForm:', e); displayError('An error occurred during reset. Check console for details.'); } } // Function to generate and download PDF async function generatePdf() { console.log('[DEBUG] generatePdf called.'); try { if (Object.keys(outputData).length === 0) { displayError("No probabilities calculated yet. Please calculate first."); return; } hideError(); // Clear error after checking const { jsPDF } = window.jspdf; const doc = new jsPDF(); const title = "Genotype Frequency to Phenotype Probability Results"; const currentDateTime = new Date().toLocaleString(); doc.setFontSize(18); doc.text(title, 105, 20, { align: 'center' }); doc.setFontSize(10); doc.text(`Date: ${currentDateTime}`, 105, 28, { align: 'center' }); let yOffset = 40; doc.setFontSize(11); doc.text('Input Genotype Frequencies:', 20, yOffset); yOffset += 7; // Draw inputs table const inputRows = Object.entries(outputData.inputs).map(([label, value]) => [label, value]); doc.autoTable({ startY: yOffset, head: [['Parameter', 'Value']], body: inputRows, theme: 'striped', styles: { fontSize: 10, cellPadding: 2, fillColor: [233, 247, 239], textColor: [51, 51, 51] }, headStyles: { fillColor: [40, 167, 69], textColor: [255, 255, 255], fontStyle: 'bold' }, columnStyles: { 0: { cellWidth: 70 }, 1: { cellWidth: 'auto' } } }); yOffset = doc.autoTable.previous.finalY + 10; doc.setFontSize(11); doc.text('Calculated Phenotype Probabilities:', 20, yOffset); yOffset += 7; // Draw results table const resultRows = Object.entries(outputData.results).map(([label, value]) => [label, value]); doc.autoTable({ startY: yOffset, head: [['Phenotype', 'Probability']], body: resultRows, theme: 'striped', styles: { fontSize: 10, cellPadding: 2, fillColor: [233, 247, 239], textColor: [51, 51, 51] }, headStyles: { fillColor: [40, 167, 69], textColor: [255, 255, 255], fontStyle: 'bold' }, columnStyles: { 0: { cellWidth: 100 }, 1: { cellWidth: 'auto' } } }); yOffset = doc.autoTable.previous.finalY + 15; // Add Disclaimer const disclaimerText = "Disclaimer: This tool is for educational and conceptual understanding only. It simplifies complex genetic principles and is NOT intended for actual genetic analysis, medical diagnosis, or any real-world scientific application. For accurate genetic analysis, consult appropriate scientific literature, specialized software, or qualified geneticists. Do not rely on this tool for critical scientific or health decisions."; const splitDisclaimer = doc.splitTextToSize(disclaimerText, 170); // Max width for text doc.setFontSize(9); doc.setTextColor(108, 117, 125); // Grey color for disclaimer doc.text(splitDisclaimer, 20, yOffset); doc.save('Genotype_Phenotype_Probabilities.pdf'); console.log('[DEBUG] PDF generated successfully.'); } catch (e) { console.error('[ERROR] Error in generatePdf:', e); displayError('An error occurred during PDF generation. Check console for details.'); } } // Ensure DOM is fully loaded before executing JavaScript that interacts with it document.addEventListener('DOMContentLoaded', function() { console.log('[DEBUG] DOMContentLoaded fired.'); try { // Initialize tab buttons array document.querySelectorAll('.tabs-container .tab-button').forEach(button => { tabButtons.push(button); }); console.log(`[DEBUG] tabButtons array populated with ${tabButtons.length} buttons.`); // Set the initial active tab const initialActiveButton = document.querySelector('.tab-button.active'); if (initialActiveButton) { switchTab('calculateTab', initialActiveButton); } else { console.warn('[DEBUG] No initial active tab button found, falling back.'); switchTab('calculateTab', null); // Fallback to ensure tab is activated } // Pre-fill default values for demonstration document.getElementById('freqAA').value = '25'; document.getElementById('freqAa').value = '50'; document.getElementById('freqaa').value = '25'; document.getElementById('dominancePattern').value = 'complete'; console.log('[DEBUG] Default values pre-filled.'); console.log('[DEBUG] DOMContentLoaded finished.'); } catch (e) { console.error('[ERROR] Error during DOMContentLoaded:', e); // This error might prevent the tool from working at all. // Display a prominent message if this fails. const appContainer = document.getElementById('toolApp'); if (appContainer) { appContainer.innerHTML = '
An critical error occurred during tool initialization. Please check your browser console for details.
'; } } });
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